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The human body is an immensely complex system of biological components, containing over 200 different types of cells that make up our organs, bones, muscles, nerves and beyond. These cells are in constant interaction with one another in order to maintain homeostasis-a state of equilibrium that ensures optimal functionality throughout the body. A good example of this balancing act is our body’s ability to regulate temperature.
One of the more prominent physiological components involved in homeostasis is the #endocannabinoidsystem (ECS), which exists in all vertebrates and regulates a host of functions including sleep, appetite, mood, pain, memory, and more. The term #endocannabinoid is derived from endogenous, meaning “from within”, and #cannabinoid, a chemical compound that interacts with certain receptors in the brain and other areas.
There are three core components of the ECS: the #endocannabinoids themselves, the receptors to which they bind, and the enzymes required to break them down once they’ve served their purpose.
Anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are the two main #endocannabinoids of interest to researchers. Anandamide has been shown to promote nerve cell generation in the brain and is sometimes referred to as the “bliss molecule” due to its ability to enhance mood and reduce anxiety (1). It’s also known for triggering a “runner’s high”, with reported high concentrations in the blood after strenuous exercise (2). Studies on 2-arachidonoylglycerol show that it can help regulate the circulatory system (3).
One aspect of AEA and 2-AG that makes them difficult to study is their rapid decomposition by enzymes in the ECS. #Endocannabinoids are synthesized and broken down as needed, and quite rapidly, whereas other neurotransmitter signals can persist for much longer or be stored for later use.
#THC and #CBD are the most common examples of phytocannabinoids, or #cannabinoids that are produced by the hemp plant. These plant-based cannabinoids interact with the same receptors as endocannabinoids, albeit in different ways. For example, #THC and anandamide both bind to cannabinoid receptors, potentially inducing a sense of calm and relaxation. However, #THC cannot be broken down by the same enzyme as anandamide, so it lingers for much longer, resulting in the distinctive, persistent high that marijuana is known for.
#Endocannabinoids would be useless without the cannabinoid receptors they bind to. The most well-known receptors in the ECS are CB1 and CB2, which have been studied extensively since their discovery in the 1990’s (4). Although found throughout the body, CB1 receptors are most commonly located in the brain and central nervous system, while CB2 receptors reside mostly in the peripheral nervous, digestive and immune systems (5).
Just like #endocannabinoids, cannabinoids such as THC and CBD bind to both CB1 and CB2 receptors, but in different ways and with different resulting effects. CBD is popular due to its widely reported therapeutic effects without the added high, and studies have suggested it to be effective against ailments ranging from #anxiety and pain to inflammation and epileptic seizures.
To understand how CBD regulates #endocannabinoid activity, one must understand the role of the enzymes that break #endocannabinoids down. The enzyme Fatty Acid Amide Hydrolase (FAAH) is responsible for breaking down AEA, while monoacylglycerol acid lipase (MAGL) breaks down 2-AG (6). Rapid decomposition of these enzymes serves to curb any overactivity that may result from heightened #endocannabinoid levels.
#CBD functions by inhibiting the FAAH enzyme, slowing down AEA’s decomposition and thereby increasing levels of that #endocannabinoid. It is speculated that this is what gives #CBD its reputation as a treatment for anxiety, as increased AEA levels are associated with a decrease in feelings of anxiousness (1).
It’s noteworthy to point out that because #CBD binds with multiple types of receptors, the full range of its effects likely extends beyond the scope of endocannabinoid regulation. Additionally, full-spectrum CBD oil contains a wide range of additional #cannabinoids, which have their own health benefits that are currently being investigated.
The #endocannabinoidsystem is still a very new subject of study to scientists, having only been discovered a few decades ago. Despite this, its role as a crucial regulatory component of some of the most important biological processes in our bodies is already widely accepted. As hemp-based products such as #CBD oil continue to rise in popularity, more information will come to light, and the remaining mysteries of the #endocannabinoidsystem will be solved.
Let me know if I can help guide you through this maze of information about CBD Oil and products. The key is to purchase only high quality products, so you can receive the full beneficial effect.
Click here to learn more and I’ll be glad to help you.
Click Here For Additional Information on CBD Oil and Products
James Donaldson is a Washington State University graduate (’79). After an outstanding basketball career with WSU, he went on to play professional basketball in the NBA with the Seattle Supersonics, San Diego/L.A. Clippers, Dallas Mavericks, New York Knicks, and Utah Jazz. He also played for several teams in the European Leagues in Spain, Italy, and Greece, and he toured with The Harlem Globetrotters to wrap up his career. James was an NBA All-Star in 1988 while playing center for the Dallas Mavericks. In 2006, James was inducted into the Pac-10 Sports Hall of Fame and also the Washington State University Athletic Hall of Fame. In 2010, James was elected as a board member for the NBA Retired Players Association.
James frequently conducts speaking engagements (motivational, inspirational, educational) for organizations, schools, and youth groups.
In 2010, James was the recipient of the NBA Legends of Basketball ABC Award, awarded for outstanding contributions in Athletics–Business–Community.
He believes in being a role model for success and professionalism to the scores of young people to whom he devotes so much of his time. He currently serves on several boards and committees and is a member of many organizations.
James believes in developing relationships that create a “Win-Win” environment for everyone involved, and in being the best he can be!
For more information about James Donaldson or to request he speak at your event, contact him at:
www.StandingAboveTheCrowd.com
JamesD@StandingAboveTheCrowd.com
1-800-745-3161 (voicemail & fax)
James Donaldson is the author of “Standing Above The Crowd” and “Celebrating Your Gift of Life” and founder of the Your Gift of Life Foundation which focuses on mental health awareness and suicide prevention, especially pertaining to our school aged children and men.
If you’re interested in having James come and speak to your group of young adults, business entrepreneurs, aspiring political and community leaders, and athletic teams, please contact him at jamesd@yourgiftoflife.org and or leave a personal message for him at 1-800-745-3161. Keep up with him and read about how he is reaching out and making a difference in the lives of so many around the world at www.yourgiftoflife.org